ea0019oc40 | Thyroid, reproduction and endocrine tumours | SFEBES2009
Chahal H
, Igreja S
, Gueorguiev M
, Quinton R
, Wass J
, Popovic V
, Ribeiro-Oliveira A Jr
, Monson J
, Akker S
, Gallego P
, Orme S
, Goldstone A
, Bevan J
, Cheetam T
, Davis J
, Clayton R
, Flanagan D
, Frohman L
, Grossman A
, Korbonits M
Background: Familial pituitary adenomas can occur in the classic syndromes of MEN-1 and Carney complex. Recently an autosomal dominant disease with incomplete penetrance has been described as familial-isolated-pituitary-adenoma (FIPA). Previous studies of familial acromegaly and gigantism disclosed germline mutations in the AIP gene located in the previously suspected chromosome 11q13 region.Aims: To analyse the prevalence of AIP-mutations in...